Association of a very high tumor mutational load with increased CD8+ and PD-1+ T-cell infiltration and improved clinical outcomes to PD-(L)1 blockade across different PD-L1 expression levels in non-small cell lung cancer.

Biagio Ricciuti,Kathryn C. Arbour,Joao Victor Machado Alessi,Navin R. Mahadevan,James Lindsay,Rileen Sinha,Natalie I. Vokes,Gonzalo Recondo,Giuseppe Lamberti,Hira Rizvi,Giulia Costanza Leonardi,Andrew J. Plodkowski,Kristen Felt,Michael Y. Tolstorukov,Pasi A. Jänne,Eliezer M. Van Allen,Lynette M. Sholl,Scott J. Rodig,Matthew D. Hellmann,Mark M. Awad

Association of a very high tumor mutational load with increased CD8+ and PD-1+ T-cell infiltration and improved clinical outcomes to PD-(L)1 blockade across different PD-L1 expression levels in non-small cell lung cancer.

2021

9018Background: Although high TMB correlates with improved outcomes to immune checkpoint inhibitors (ICI) in patients (pts) with non-small cell lung cancer (NSCLC), an optimal TMB cutoff to discrim...

Keywords:

in patient
pd l1 expression
Cancer research
Lung cancer
non small cell
Medicine
Blockade
CD8
t cell infiltration
immune checkpoint inhibitors

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