Quantitative analysis of inner retinal structural and microvascular alterations in intermediate age-related macular degeneration: a swept-source OCT angiography study.

Abstract Purpose To investigate the structural and microvascular alterations of the inner retinal layers in patients with intermediate age-related macular degeneration (iAMD), and determine an association between structural and microvascular parameters Methods In this prospective study, 58 eyes of iAMD patients and 64 age and sex-matched control eyes were enrolled. Participants underwent spectral-domain optical coherence tomography (OCT) and swept-source OCT angiography (OCTA) imaging. Retinal layer segmentation was performed automatically using the built-in software of the OCT device. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), and outer plexiform layer (OPL) thicknesses were analyzed in the central and parafoveal region. Foveal avascular zone (FAZ) area and vessel density of the superficial and deep capillary plexuses (SCP and DCP) in the fovea and parafoveal region were obtained. Results In iAMD eyes, the RNFL, GCL, and IPL were significantly thinner compared to control eyes in the parafovea (p   0.05 all). The ganglion cell complex was significantly correlated with SCP vessel density measurements in iAMD eyes (r = 0.224, p = 0.043). Conclusion This study demonstrates that inner retina is also affected in iAMD in terms of structural and microvascular components. Inner retinal thinning is significantly correlated with vessel density reduction, suggesting a cause and effect relationship between these parameters. Further longitudinal studies may aid in characterizing these alterations and better understanding the AMD pathogenesis.