N-brain natriuretic peptide: correlation with tricuspid insufficiency in Gaucher disease

Summary NT-pro-brain natriuretic peptide (NT-proBNP) values are correlated with right ventricle dysfunction in pulmonary hypertension and have been recommended as a prognostic marker for symptomatic primary pulmonary hypertension. The purpose of this pilot study was to determine whether NT-proBNP values correlate with mild to moderate pulmonary hypertension in Gaucher disease. The NT-proBNP assay was performed on sera from patients with type I (non-neuronopathic) Gaucher disease who were known to have tricuspid insufficiency (TI) gradient values on echocardiography that were normal (TI p =0.05) between mean NT-proBNP values and TI gradient group: mean NT-proBNP for normal TI gradient ( n =20 patients)=133.3 (range: 46–445) pg/ml; mean NT-proBNP for borderline TI gradient ( n =17 patients)=288.7 (range: 81–1088) pg/ml; and mean NT-proBNP for elevated TI gradient ( n =10 patients)=1034.2 (73–6703) pg/ml. Treatment status was not correlated with TI gradient or NT-proBNP values. Thus, in this pilot study of Gaucher disease that included patients with mild to moderate pulmonary hypertension, NT-proBNP was correlated with echocardiographic findings. Further studies will be required to ascertain if NT-proBNP can be used for diagnosis and monitoring of these patients.