Antihypertensive effect of ragaglitazar: A novel PPARα and γ dual activator

Abstract Ragaglitazar is a novel and potent dual peroxisome proliferators activated receptor (PPAR) α and γ activator. The aim of this study is to investigate the effect of ragaglitazar on blood pressure and endothelial function in insulin resistant animal model and non-insulin resistant hypertensive models. The effects ragaglitazar were tested in Zucker fa/fa, spontaneously hypertensive rats (SHR), 2 kidney 1clip rat (2K1C) and Wistar Kyoto rats (WKY). Pioglitazone was taken as a comparative standard. Ragaglitazar showed significant reduction ( P −1 ) showed significant ( P P