Guillain Barre Syndrome: Predictors of Requirement of Mechanical Ventilation (P5.068)

OBJECTIVE: Identify demographic factors and medical comorbidities as predictors of requirement of invasive mechanical ventilation (IMV) in patients with Guillain Barre Syndrome (GBS). BACKGROUND: Nationwide inpatient database studies identifying predictors of need for IMV in GBS are lacking. DESIGN/METHODS: Retrospective search of Nationwide Inpatient Sample (NIS) was done to identify patients with primary diagnosis of GBS (ICD-9 code 357.0) who received treatment with intravenous immunoglobulin (IVIG; ICD-9-CM procedure code 99.14) or Plasma Exchange (PLEX; ICD-9-CM procedure codes 99.71, 99.76). Primary outcome was requirement of endotracheal intubation (ICD-9-CM procedure codes 96.04, 96.05) or invasive ventilation (ICD-9-CM procedure codes 96.70, 96.71, 96.72). Patient demographics, hospital characteristics and comorbidities were used as predicting variables. Multivariate logistic regression were used to identify predictors for requirement of IMV. RESULTS: Total 3438 patients of GBS who received treatment (IVIG 51.3[percnt]; PLEX 44[percnt]; PLEX+IVIG 4.7[percnt]) were identified from year 2002 to 2011, out of which 570 (16.6[percnt]) patients required IMV. Every decade increment in age, teaching hospital status, presence of congestive heart failure and chronic lung disease were significant predictors of IMV in multivariate analysis. CONCLUSIONS: In patients admitted for GBS, every decade increase in age, teaching hospital status and comorbidities including congestive heart failure and chronic lung disease were predictors of requirement of IMV. Study Supported by: Disclosure: Dr. Dharaiya has nothing to disclose. Dr. Modi has nothing to disclose. Dr. Naqvi has nothing to disclose.