Poster Session : PS 0594 ; Critical Care Medicine ; Prognostic Factors in Cholinesterase Inhibitor Poisoning

Background: Organophosphate poisoning and carbamates are potent cholinesterase inhibitors that have a high mortality. The aim of this study is to investigate the prognostic factors affecting survival in patients with cholinesterase inhibitor poisoning (CIP). Methods: This study included 92 patients with CIP from January 2005 till August 2013. We divided these patients into two groups (survivors vs non-survivors), compared clinical characteristics, and analyzed the predictors of survival. Results: The mean age of the included patients was 56 years (range, 16-88). The patients included 57 (62%) men and 35 (38%) women. Comparing clinical characteristics between survivor group (n=81, 88%) and non-survivor group (n=11, 12%), there were no differences in renal function, pancreatic enzyme, and serum cholinesterase level except serum bicarbonate level and APACHE II score. The serum bicarbonate level was lower in non-survivors than in survivors (12.45 ± 2.84 vs 18.36 ± 4.73). The serum APACHE II score was higher in non-survivors than in survivors (24.36 ± 12.07). The development of pneumonia during hospitalization was higher in non-survivor than in survivor (n=9, 82% vs n=31, 38%). In multiple logistic regression analysis, serum bicarbonate concentration, APACH II score, pneumonia during hospitalization were the important prognostic factors in patients with CIP. Conclusions: Serum bicarbonate and APACHE II score are useful prognostic factors in patients with CIP. Furthermore, pneumonia during hospitalization was also important to predict the prognosis in patients with CIP. Therefore, prevention and aggressive treatment of pneumonia is important in treatment of patients with CIP.