An efficient method for selective amino acid protection of meso-2,2′-diaminodicarboxylic acid: An improved synthesis of FK-156

An efficient method for selective amino acid protection with proper differentiation between the two amino acid groups in meso-2,2′-diaminopimelic acid has been achieved [7 → 8 → 9 → 10 → 11] and applied to the synthesis of FK-156 [10 → 12 → 14 → 1].