[Expression of cyclin-dependent kinase CDC2 and its significance in malignant progression of gliomas].

Zhai Dz,Huang Q,Zhu Q,Huo Hm,Dong J,Qian Zy,Wang Ad,Lan Q

[Expression of cyclin-dependent kinase CDC2 and its significance in malignant progression of gliomas].

2007

Zhai Dz
Huang Q
Zhu Q
Huo Hm
Dong J
Qian Zy
Wang Ad
Lan Q

细胞周期蛋白依赖性激酶CDC2属于ser/thr蛋白激酶家族,在细胞周期G2至M期起关卡作用,无论是细胞进入还是走出增殖周期都与它的表达有关.文献报道,CDC2过度表达可使细胞周期进程紊乱,导致许多组织形成肿瘤.我们应用组织芯片和免疫组织化学技术检测了CDC2在人脑胶质瘤组织及其相关起源细胞中的表达,以探讨CDC2的表达与胶质瘤发生、发展的关系.

Keywords:

Cyclin-dependent kinase 1
Cyclin-dependent kinase
Cancer research
Biology
malignant progression
Medicine

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