Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV.

Michael G. Overstreet,Alison Gaylo,Bastian R. Angermann,Angela Hughson,Young-Min Hyun,Kris Lambert,Mridu Acharya,Alison C. Billroth-MacLurg,Alexander F. Rosenberg,David J. Topham,Hideo Yagita,Minsoo Kim,Adam Lacy-Hulbert,Martin Meier-Schellersheim,Deborah J. Fowell

Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV.

2013

Michael G. Overstreet
Alison Gaylo
Bastian R. Angermann
Angela Hughson
Young-Min Hyun
Kris Lambert
Mridu Acharya
Alison C. Billroth-MacLurg
Alexander F. Rosenberg
David J. Topham
Hideo Yagita
Minsoo Kim
Adam Lacy-Hulbert
Martin Meier-Schellersheim
Deborah J. Fowell

Inflammation induces changes in the extracellular matrix density and composition. Fowell and colleagues show that CD4+ effector T cells use integrin αV for interstitial migration on fibronectin in inflamed tissues.

Keywords:

Cell biology
Inflammation
Immunology
Regulation of gene expression
Fibronectin
Integrin alphaV
Biology
Effector
Extracellular matrix
Integrin
Dermis

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