A splicing isoform of TEAD4 attenuates the Hippo-YAP signalling to inhibit tumour proliferation

The Hippo/Yap signalling pathway is found deregulated in several cancers. Here, the authors uncover an additional mechanism of YAP regulation that occurs via alternately spliced isoform of TEAD4, which acts as a dominant negative regulator of YAP-TEAD signalling.