Synthesis and SAR of Sulfonyl- and Phosphoryl Amidine Compounds as anti-Resorptive Agents.

Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors.