Intrinsic catalytic activity of rhodium nanoparticles with respect to reactive oxygen species scavenging: implication for diminishing cytotoxicity

Noble metal nanoparticles (NPs) and their hybrids have demonstrated a strong potential to mimic the catalytic activity of natural enzymes and diminish oxidative stress. There is a large space to explore the intrinsic catalytic activity of Rh NPs with respect to reactive oxygen species (ROS) scavenging. We found that Rh NPs can quench H₂O₂, •OH, O₂•⁻, ¹O₂ and inhibit lipid peroxidation under physiological conditions. In vitro cell experiments proved that Rh NPs have great biocompatibility and protect cells from oxidative damage caused by H₂O₂. This study can provide important insights that could inform future biological applications.