Study on molecular mechanism of Euodiae Fructus on liver toxicity in MICE

OBJECTIVE: To study the molecular mechanism of extracts from Euodia rutaecarpa on hepatotoxicity in mice. METHOD: Totally 30 KM mice were divided into 3 groups and orally administrated extracts from E. rutaecarpa for consecutively 15 days. The expressions of Erkl/2, CDK8, CK1e, Stat3 and Src were detected by Western blotting method. RESULT: The extracts from E. rutaecarpa could up-regulated Erkl/2, CDK8 and CK1e expressions (P <0.01) and down-regulate Stat3 and Src (P <0.01). CONCLUSION: The molecular mechanism of E. rutaecarpa on hepatotoxicity may be correlated with Erkl/2, CDK8, CKle, Stat3 and Src signal molecules.