Adverse Obstetric Outcomes Associated With In Vitro Fertilization in Singleton Pregnancies: A Prospective Cohort Study.

Objective:To compare the obstetric outcomes of women treated with in vitro fertilization (IVF), women with indicators of subfertility but without assisted reproductive technologies, and fertile women with singleton pregnancies.Methods:A prospective cohort study was conducted from March 2013 to February 2016 at the Hunan Provincial Maternal and Child Health Hospital in China. Finally, 1260 eligible mothers were recruited into the IVF group, 1899 into the subfertile group, and 2480 into the fertile group.Results:Compared to the fertile group, gestational diabetes mellitus (adjusted odds ratio [aOR] = 2.36; 95% confidence interval [CI]: 1.67-3.34), pregnancy-induced hypertension (aOR = 2.23; 95% CI: 1.37-3.64), placenta previa (aOR = 4.11; 95% CI: 2.12-7.96), premature rupture of membranes (aOR = 4.60; 95% CI: 2.71-7.81), anemia in pregnancy (aOR = 2.17; 95% CI: 1.42-3.31), preterm birth (PTB; aOR = 2.19; 95% CI: 1.59-3.02), low birth weight (aOR = 2.82; 95% CI: 2.02-3.94), perinatal mortality (aOR = 2.72; 9...