Process for producing particle s (+) - ibuprofen.

1995 
A METHOD FOR PRODUCING PARTICLE S (+) Ibuprofen WITH IMPROVED FLOW PROPERTIES; THICK PARTICLE S (+) - ibuprofen melt and melt DISTRIBUTED IN FINELY a non-solvent, preferably water cold and cool quickly. This cooling PRODUCE FINE CRYSTAL a primary structure, which agglomerates in a secondary structure. IN THIS SECONDARY STRUCTURE PRODUCT allowed to settle and obtained as filter residue, and allowed to dry. These particles are APPROPRIATE FOR TABLETS compression COMPOUNDS AUXILIARY optionally adding tableting and manufacture delayed release tablets of active ingredient.
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