PE-137 : Promising Fe3O4/CdSe Nanocomposites for Rug Delivery in Liver Cancer Treatment

Aims: Nowadays, magnetic semiconductors nanocomposites have become a new class of materials of great importance promising with new properties and exploiting unique incorporation between materials. For example, one can make use of a variety of spin-related phenomena, not readily available in other materials. this work concentrates on synthesis of magnetic iron oxide nanoparticles (MNs) and Cadmium Selenide (CdSe) quantum dots (QDs). CdSe QDs have attractive optical properties such as bright fluorescence emission and wide absorption band in the visible region and they possess the ability to act as energy donors through Forster resonance energy transfer (FRET). MNs also are known to have interesting applications in biomedical field and drug delievery system. Methods: In the present work, bi-functional magnetic-luminescent nanocomposites with Fe3O4 nanoparticles as the cores and CdSe as the shells have been synthesized by a facile direct precipitation method. Transmission electron microscopy (TEM) images revealed that the obtained bi-functional nanocomposites had a core-shell structure. The flower shape has been ascribed to the inhomogeneous growth of CdSe due to the presence of many active sites which turn to be nucleation centers for the CdSe on the surface of the nano-magnetite. The X-ray diffraction (XRD) patterns ensured the cubic spinel structure of the Fe3O4 core. Results: Magnetic measurements indicated that the presence of CdSe in the composite has reduced its magnetic properties. Optical measurements of the Fe3O4/CdSe nanocomposites showed that the prepared samples have dual functions, optical tunable band gap similar to the semiconductor quantum dots and magnetic properties due to Fe3O4 nanoparticles. According to the values of Stokes shift of the new hybrid composites, one can suggest that they may be promising in drug delivery (liver cancer treatment). All of the first line of result idicate that all of fabricated samples are so promising in drug delivery system. Conclusions: Fe3O4 nanoparticles has been successfully prepared by the co-precipetation method. The have been investigated via XRD, TEM and VSM. The XRD confirms the formation of the required cubic ferrite without other unwanted phases. The Fe3O4has been used as a seed or as a core to grow CdSe nanoshell around. The obtained hybrid Fe3O4 nanostructure has flower shape particles. The Fe3O4/CdSe nanocomposites has larger quantum yield values thanthose of pure CdSe QDs may be due to the fact that magnetic nanoparticles facilitate the electron holerecombination and enhance the emission from the quantum dots. In other words, the presence of Fe3O4 enhances the optical properties of CdSe quantum dots. The prepared nanocomposites have dual functions, optical tunable band gap similar to the semiconductor quantum dots and magnetic properties due to Fe3O4nanoparticles. This composite would be considered as dilute magnetic-semiconductor and could be used in spintronics, biosensors, solarcells and biomedical lables which could confirm that these nanoparticles could be a suitable drug delievery tool for many anticancer agent in the future.