Апоптоз и патология почек

The review gives an idea of impact of some molecular mechanisms of apoptosis on the development of nephropathies of various origins. Ways of realization and contribution of molecules (р53, PUMA, MDM2, р21) in renal disease associated with glomerular injury, ischemia, in the development of renal failure and their participation in the progression and prognosis of renal disorders were described. A subtle mechanism of the effect of the molecule р53 on cancerogenesis is revealed. The expression of р53 protein defines a nephrotoxicity of a number of chemotherapeutic drugs. Changes and influence of a proapoptotic protein PUMA were defined only in a context of cancerogenesis and nephrotoxicity. The role of a molecule MDM2 as predictor of cancerogenesis and clinical course of lupus nephritis is considered. Role of molecule MDM2 as a predictor of neoplastic proliferationand evolution of lupus nephritis was studied. The senescence marker, р21 molecule makes a contribution to development of acute renal failure, focal-segmental glomerulosclerosis, diabetic nephropathy, autoimmune disorders in kidneys. Recognizing apoptosis as one of mechanisms in development of kidney diseases, this review gives strong incentive for further research and discovery of innovative approaches for prevention, prognosis and treatment of nephropathies.