The effect of basic periodontal therapy on the tumor necrosis factor-alpha in serum and gingival crevicular fluid in diabetes patients with periodontitis

Objective The aim of this study was to evaluate the effects of basic periodontal therapy on the level of tumor necrosis factor-alpha in serum and gingival crevicular fluid,clinical periodontal measurements,glycemic control in type two diabetic patients (T2DM) with chronic periodontitis.Methods Sixty patients with type two diabetes and chronic periodontitis,randomly divided into basic periodontal therapy group (observation group) and non-basic periodontal therapy group (control group),and each group was 30 patients.All subjects received basic periodontal therapy.Clinical periodontal parameters:probing depth (PD),attachment loss(AL),and plaque index (PLI) were recorded at baseline,1 and 3 months after the treatment,HbA1c and the level of TNF-α in serum and gingival crevicular fluid were measured.Results At 1 and 3 months after treatment,PD,PLI and TNF-α in gingival crevicular fluid significantly reduced (P ＜ 0.05) in observation group,but AL and the concentration of HbAlc and TNF-α in serum reduced significantly 3 months after treatment (P ＜ 0.05),while that of control group had no significant difference after the treatment (P＞0.05).Conclusion The basic periodontal therapy can help to control the glucose level,clinical periodontal improvements and decreases TNF-α in serum and gingival crevicular fluid in type two diabetic patients with periodontitis. Key words: Basic periodontal therapy; Type 2 diabetes; Tumor necrosis factor-alpha; Glycated hemoglobin A1c