FOXP3 + Treg Cells and Systems Biology Approaches to Studying Their Function

Regulatory T (Treg) cells play a key role in immunological homeostasis in health and disease. The molecular mechanisms underlying the differentiation, maintenance and function of Treg cells remains largely unclear. However, recent studies have shown that Treg development is not simply controlled by a series of linear signaling pathways, but rather a complex and dynamic regulatory network. This section provides an overview of the applications of systems biological tools in the Treg field. These approaches have brought to the field new insights into the complexities of Treg biology.