For use in the regulation and treatment of skin diseases claudin-mediated function, a pharmaceutical composition comprising a prostaglandin derivative

The present disclosure provides a pharmaceutical composition for modulating the claudin-mediated function in a mammalian subject, comprising administering a specific fatty acid derivatives effective amount to a subject in need thereof, a pharmaceutical composition. The present invention also are those with the same fatty acid derivative as described above, it discloses a method for regulating the expression of treatment methods and claudin skin disorders in a mammalian subject.