Probing various pro and con health aspects of the glucose–insulin system in non-diabetics: focusing on insulin resistance and dietary implications

Abstract Despite the variations in age, gender, and ethnicity among subjects, important significant correlations are found between fasting blood glucose (FBG) as a surrogate for insulin resistance (IR) and many elements of the metabolic syndrome (MS). It is quite reasonable to believe that maintaining relatively low levels of FBG representing the optimal status of insulin sensitivity appears to ameliorate many adverse manifestations of the MS and favors longevity. Accordingly adapting a best possible lifestyle via good dietary and exercise practices to keep IR in check has the potential to extend useful lifespan.