The expression of LGR5 and Cath-D in thyroid papillary carcinoma and their clinical significance

Objective: To study the relationship between the expression of LGR5 and Cath-D in papillary thyroid carcinoma and clinicopathological parameters. Methods: The expression of LGR5 and Cath-D was detected in 67 cases ofthyroid papillary carcinoma and paired adjacent normal thyroid tissues by immunohistochemical staining. In different clinicopathological parameters such as gender,age,tumor size,lymph node metastasis( LNM),local invasion,TNM staging,LGR5 and Cath-D positive expression rate were analyzed. Results: The positive expression rates of LGR5 and Cath-D in papillary thyroid carcinoma were significantly higher than those in adjacent normal tissues( P 0. 05). Conclusion: The expression of LGR5 and Cath-D in thyroid papillary carcinoma is closely associated with local invasion and LNM,The LGR5 and Cath-D may be good marker for poor prognosis of papillary thyroid carcinoma.