Diagnostic Efficacy of FibroScan for Liver Inflammation in CHB Patients: A Single-Center Study with 1,185 Liver Biopsies as Controls

Background: It is important for chronic hepatitis B(CHB) to evaluate liver inflammation by noninvasive method. Fibroscan based on the transient elastography (TE) techniques is a noninvasive method widely used in the evaluation of liver fibrosis. We aimed to assess the efficacy of Fibroscan in the diagnosis of liver inflammation in patients with CHB. Methods: Ultrasound-guided liver biopsy was completed within one month after FibroScan testing in 1,185 CHB patients. Both the reliability criteria( interquartile range to median,IQR/M) of FibroScan and the quality of liver biopsy(complete portal tracts, CPTs) were well assured. The liver inflammation grading was classified into five grades (G0~G4).With liver biopsies as controls,the diagnostic efficacy of Fibsocan in the diagnosis of liver inflammation in CHB patients was evaluated by the receiver operating characteristic (ROC) curve. This study was registered with chictr.org.cn.This study was registered with chictr.org.cn, number ChiCTR-DRD-16009773. Findings: The liver stiffness measurement (LSM) reliability results of IQR/M were respectively 70% (IQR/M≤0.10),23% (0.100.10

Keywords:

• Single Center
• Gastroenterology
• Transient elastography
• Interquartile range
• Inflammation
• Liver biopsy
• Medicine
• Biopsy
• Traditional Chinese medicine
• Receiver operating characteristic
• Internal medicine

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