Calixarene Methylenebisphosphonic Acids: Alkaline Phosphatase Inhibition and Docking Studies
2008
The inhibition of alkaline phosphatase from bovine intestine mucosa and bovine kidney by calix[4]arenes functionalized at the marcocyclic upper rim by one or two methylene bisphosphonic acid fragments have been investigated. The mechanisms of enzyme inhibition have been discussed using a molecular docking approach by computational modeling of inhibitors into active centers of E. coli alkaline phosphatase.
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