Anesthetic Considerations of a Surgical Patient with Favism: A Case Repor

Rationale: Favism is a genetic disease of Glucose 6 phosphatase dehydrogenase (G6PD) deficiency in human red blood cells. It is mainly due to the mutation of G6PD gene encoded on the X chromosome, which leads to the decrease of G6PD activity or deficiency. G6PD plays important roles in the metabolic process of human body. One of them is to protect the integrity of the erythrocyte membrane. When the body is lack of G6PD or its activity is reduced, the patient is prone to hemolysis after eating oxidant, such as fresh broad bean, or under strong stress.Patient concerns and diagnoses: A 43 year old male patient diagnosed with lumbar intervertebral disc herniation was hospitalized and planned for a surgery of the lumbar spine under general anesthesia. The patient was diagnosed as favism at an early age, but in later growth and life there was no hemolysis due to the doctor's instructions.Anesthesia: We chose total intravenous anesthesia and avoided some drugs which may induce hemolysis. During the operation, we monitored the heart rate, blood pressure, blood gas and urine indicators to determine whether the patient had hemolysis and actively deal with it.Result: During the process, the patients' circulation and respiration was stable, the operation was smooth, and we followed up him the first-third 7th day after the surgery. The patients recovered well and had no acute hemolytic reaction. It can be seen that our treatment may provide some experience for postoperative anaesthesia of patients with broad bean disease.