Progressive cardiovascular disease in a patient under treatment with nilotinib.

Abstract The development of cardiovascular disease (CVD) appears in subjects with several cardiovascular risk factors (CVRF). However, other agents could be related to the appearance of CVD, like chemotherapy drugs. We present a 63 years-old man with very high cardiovascular risk (CVR) and chronic myeloid leukemia under treatment with nilotinib. Despite a good control of cardiovascular risk factors, he development a severe and acceleratted peripherical arterial disease (PAD). PAD occurs in 5–20% patients under treatment with nilotinib and it is more frecuently in subjects with several CVRF.