Lung elastic recoil and ventilation heterogeneity of diffusion-dependent airways in older people with asthma and fixed airflow obstruction
2019
Small airways are abnormal in asthma [1]. One measurement of small airway function is Sacin, derived from the multiple breath nitrogen washout (MBNW) test. Sacin reflects ventilation heterogeneity in diffusion-dependent airways and is correlated with airway hyper-responsiveness [2] and asthma control [3]. Theoretically, heterogeneity of diffusion-dependent ventilation can arise due to the heterogeneity of cross-sectional areas of airway openings in terminal airways and the acini [4].
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This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.
Conflict of interest: Dr. Tonga has nothing to disclose.
Conflict of interest: Dr. Berend reports personal fees from GlaxoSmithKline, outside the submitted work.
Conflict of interest: Dr. Thamrin has nothing to disclose.
Conflict of interest: Dr. Farah has nothing to disclose.
Conflict of interest: Dr. Jetmalani has nothing to disclose.
Conflict of interest: Dr. Chapman has nothing to disclose.
Conflict of interest: Dr. King has nothing to disclose.
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