THE EVALUATION OF RISK FACTORS OF CARDIO-VASCULAR DISEASES IN PATIENTS WITH DIABETES MELLITUS TYPE II DEPENDING ON DEGREE OF COMPENSATION OF CARBOHYDRATE METABOLISM AND IN TREATMENT DYNAMICS

The study was carried out using sampling of 74 patients (20 males and 54 females) aged from 48 to 75 years (average age 61.5±7.4 years) with diabetes mellitus type II. The analysis was applied to anthropometric parameters, lipid metabolism condition, level of highly sensitive C-reactive protein, tumor necrosis factor-α depending on degree of compensation of carbohydrate metabolism-level of glycosylated hemoglobin (HbA1c). In patients with diabetes mellitus type II with worse compensation of carbohydrate metabolism (HbA1c>7,5%) their body mass, waist circumference, body mass index occurred higher than in patients with HbA1c≤7,5%. The level of highly sensitive C-reactive protein corresponding to risk of development of cardio-vascular diseases was established in 97% of patients and increased level of tumor necrosis factor-α was established in 66% of patients independently of indices of glycemia. The patients were divided in 2 groups. The group I included 50 patients whose treatment was supplemented with mimetic of glucagon-like peptide Exenatid in the mode of double subcutaneous injections in dosage of 5 mkg 2 t per day during a month and then 10 mkg 2t per day during 5 months. The control group included 20 patients receiving a standard sugar-decreasing therapy. The initially analyzed indices had no statistically reliable differences in both groups. In patients of both groups a reliable decreasing of HbA1c was established in 6 months. Only in patients of group I statistically reliable amelioration of lipid specter, decreasing of body mass, waist circumference and level of markers of non-specific inflammation: highly sensitive C-reactive protein and tumor necrosis factor-α.