The GC/TOFMS based Serum Metabolomics in Rats with Depression-like Behaviorafter Exposure and Re-exposure to Chronic Unpredictable Mild Stress

The Recurrent depression leads to disability and high health care costs. Identification of biomarkers for diagnosis recurrent depression will be helpful to predict and prevent the recurrence of depression. Sprague-Dawley rats were exposed and re-exposed to chronic unpredicted mild stress to mimic onset and recurrent depression. Rat’s serum was collected and analyzed by gas chromatography/time-of-flight mass spectrometry. Palmitinic acid and oleinic acid were found decreased in the onset depression and alanine, 6-Desoxy-Mannopyranose, oleinic acid, stearic acid, cholesterol was found decreased in recurrent depression. These data shows rats suffer recurrent depression have much more serious metabolic disturbance than onset depression, and they may provide valuable information for the potential biomarkers of distinguish onset and recurrent depression.