Quercetin as a potential nutraceutic against coronavirus disease 2019 (COVID-19)

Introduction: The coronavirus disease 2019 (COVID-19) is a viral disease that affects several human organs and systems Preventive or prophylactic treatments are specifically useful in emerging infectious diseases such as COVID-19 because they reduce the need for hospitalization and public health spending Although the SARS-CoV-2 preventive effect of several therapeutic agents (e g , hydroxychloroquine/chloroquine, remdesivir, lopinavir, and ritonavir) has been extensively evaluated, none of them have demonstrated significant clinical efficacy Method: We aim to address and discuss the recently published studies on the chemoprophylactic potential of quercetin against SARS-CoV-2 A literature search was carried out on different databases, such as PubMed/MEDLINE, Scielo, Scopus, Web of Science, Cochrane Library, and Clinical Trials gov Studies that report the effect of quercetin against SARS-CoV-2 or other types of coronaviruses were included and critically evaluated Results: Studies have shown that quercetin, an FDA-approved flavonoid used as an antioxidant and anti-inflammatory agent, inhibits the entry of coronavirus (SARS-CoV) into the host cell Moreover, an in silico study showed that quercetin is a potent inhibitor of the SARS-CoV-2 main protease (Mpro), suggesting that this flavonoid is also active against COVID-19 Conclusions: Because quercetin might prevent and lessen the duration of SARS-CoV-2 infections, it is plausible to assume that the prophylactic use of this flavonoid produces several clinical benefits However, this preliminary evidence needs to be confirmed by in vitro assays and, posteriorly, in randomized clinical trials (English) [ABSTRACT FROM AUTHOR] Introduccion: La enfermedad del coronavirus 2019 (COVID-19) es una enfermedad viral que afecta a varios organos y sistemas Los tratamientos preventivos o profilacticos son especialmente utiles en enfermedades infecciosas emergentes como COVID-19 porque reducen la necesidad de hospitalizacion y el gasto en salud publica Aunque el efecto preventivo del SARS-CoV-2 de varios agentes terapeuticos (e g , hidroxicloroquina/cloroquina, remdesivir, lopinavir y ritonavir) se ha evaluado ampliamente, ninguno de ellos ha demostrado una gran eficacia clinica Metodo: Por lo tanto, aqui nuestro objetivo es abordar y discutir los estudios publicados recientemente sobre el potencial quimioprofilatico de la quercetina contra el SARS-CoV-2 Metodologia: Se realizo una busqueda de la literatura en bases como PubMed/MEDLINE, Scielo, Scorpus, Web of Science, Cochrane Library y Clinical Trials gov Se incluyeron y evaluaron criticamente estudios que abordan la quercetina contra el SARS-CoV-2 u otros tipos de coronavirus Resultados: Algunos estudios han demostrado que la quercetina, un flavonoide aprobado por la FDA que se utiliza como agente antioxidante y antiinflamatorio, inhibe la entrada del coronavirus (SARS-CoV) en la celula huesped Ademas, un estudio in silico mostro que la quercetina es un potente inhibidor de la proteasa principal del SARSCoV- 2 (Mpro), lo que sugiere que este flavonoide tambien es activo contra COVID-19 Conclusiones: Debido a que la quercetina podria prevenir y disminuir la duracion de las infecciones por SARSCoV- 2, es plausible suponer que el uso profilactico de este flavonoide produce varios beneficios clinicos Pero, estas pruebas preliminares deben ser confirmadas mediante ensayos in vitro y, posteriormente, en un ensayo clinico aleatorizado (Spanish) [ABSTRACT FROM AUTHOR] Copyright of Ars Pharmaceutica is the property of Facultad de Farmacia de Granada and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )