Carbon Monoxide (CO)-Induced Delayed Amnesia and Delayed Neuronal Death

Recent evidence has indicated that ischemia produces several dysfunctions in the central nervous system. For example, in the passive avoidance task, amnesia is induced 24 hours after ischemia in rats (Yasumatsu et al., 1987; Yamazaki et al., 1984). In addition, “delayed neuronal death” is caused even after the recovery from changes in biochemical and electrophysiological parameters induced by ischemic insult (Kirino, 1982; Pulsinelli et al., 1982).