Radiosensitivity enhancement of typical 15 nm polyethylene-glycol-coated Au nanoparticles on HepG2 cell
2014
Objective To investigate the radiosensitivity enhancement of Au nanoparticles to HepG2 cell.Methods 15 nm polyethylene-glycol-coated(PEG) Au nanoparticles were synthesized,and then blood stability were tested by using the UV-vis optical absorption.Meanwhile,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide methods were used to investigate the cell viability after 24 and 48 hours treatments,and cloning formation were used to investigate the radiosensitivity enhancement.Results It was found that PEG-coated Au nanoparticles presented a high blood stability,and surface plasmon response has not shown significant changes after 24 hours.Cell viability was decreased after 24 hours treatment,but it was recovered to 90% after 48 hours.Cloning formation showed Au nanoparticles presented a significant radiosensitivity enhancement.Conclusion 15 nm PEG-coated Au nanoparticles presented a good blood stability,low cytotoxicity and high radiosensitivity enhancement.
Key words:
Polyethylene glycols; Gold nanoparticles; Radiation sensitizing
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