Manufacturing device and manufacturing method of large-size bone scaffold

The invention discloses a manufacturing device and a manufacturing method of a large-size bone scaffold. The manufacturing device comprises a three-dimensional motion working framework, an extrusion mechanism, a temperature control unit, a control panel and a working table, wherein the temperature control unit comprises a heating unit and a movable platform capable of driving the heating device to perform three-dimensional motion; the heating unit is controlled by the control panel; the temperature control unit is fixedly arranged on the working table; the extrusion mechanism and the working table are arranged on the working framework. The manufacturing device of the bone scaffold is simple in structure, convenient to operate and low in manufacturing cost; by use of the characteristics of bio-ink and accurate control of the control panel over the heating temperature according to the size of the scaffold, so that manufacturing of porous bone scaffold structures which have large size in a height direction and are different in shape is realized, and a beneficial material and technical support are provided for large bone defect treatment.