Novel porphyrin–psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies

Dalip Kumar,Bhupendra Mishra,K. P. Chandra Shekar,Anil Kumar,Kanako Akamatsu,Ryohsuke Kurihara,Takeo Ito

Novel porphyrin–psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies

2013

Dalip Kumar
Bhupendra Mishra
K. P. Chandra Shekar
Anil Kumar
Kanako Akamatsu
Ryohsuke Kurihara
Takeo Ito

A Cu(I)-catalyzed azide–alkyne cycloaddition reaction (CuAAC) has been utilized to prepare novel triazole-linked cationic porphyrin–psoralen conjugates that exhibited significant photocytotoxicity against A549 cancer cells (IC50 = 84 nM).

Keywords:

Cationic polymerization
Psoralen
Combinatorial chemistry
Cancer cell
Porphyrin
DNA
Conjugate
Organic chemistry
Chemistry
Stereochemistry
Cytotoxicity
Cycloaddition

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations