Hidden Figures: A Non-translated RNA Regulates Axonal Neurotrophin Signaling

In this issue of Neuron , Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3′ UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors.