Effect of traditional Chinese medicine Jieduyin on inflammatory response after bone trauma

Objective To evaluate the effect of Jieduyin decoction on inflammatory response after trauma and orthopedic surgery. Methods The study enrolled 100 patients undergone trauma and orthopedic surgery between June 2013 and May 2014. All the subjects were assigned to study group and control group with 50 cases for each according to the random number table. In study group the subject had Jieduyin decoction, but 5 g/ml sugar water in control group for 7 consecutive days. Parameters measured after operation included white blood cell (WBC) count, serum tumor necrosis factor-α(TNF-α), interlukin-6 (IL-6), incidence of systemic inflammatory response syndrome (SIRS) and SIRS score. Results Notable increases in WBC count, TNF-α as well as IL-6 were seen in both groups at postoperative 1 day, but the differences between the two groups were all insignificant (P>0.05). These parameters presented some decreases at postoperative 3, 5 and 7 days, greater in study group than in control group (P 0.05), but there were significant differences at postoperative 3, 5 and 7 days (P<0.05). Conclusion Jieduyin can ameliorate the excessive inflammatory response, reduce inflammatory levels of the peripheral blood, and decrease the incidence of SIRS, which indicates a good therapy for the systemic inflammatory response following trauma and orthopedic surgery. Key words: Inflammation; Wounds and injuries; Drugs, Chinese herbal