Bis(phosphite) Ligands with Distal Regulation: Application in Rhodium‐mediated Asymmetric Hydroformylations

Small amounts of achiral polyether binders are employed to enhance the enantioselectivity of the hydroformylation of an array of diversely substituted substrates (increase of up to 62 % ee for vinyl acetate) mediated by chiral rhodium complexes derived from the α,ω-bis(phosphite)–polyether ligands 1. To the best of our knowledge, this study represents an unprecedented successful example of the positive regulation of enantioselectivity in hydroformylations.