Case of lipoatrophic diabetes induced by juvenile dermatomyositis

Lipodystrophy is a rare condition that is often accompanied by one or more metabolic diseases. Here we report a case of lipoatrophic diabetes induced by juvenile dermatomyositis. Although pioglitazone was not effective for lowering blood glucose levels, our observation suggested that it improved liver function slightly. The effectiveness of metreleptin for lowering blood glucose levels could not be determined, as we administered it in short period. Liver biopsy revealed burned-out nonalcoholic steatohepatitis. Our results indicate that the successful treatment of lipoatrophic diabetes induced by juvenile dermatomyositis requires an early diagnosis and therapeutic intervention. This article is protected by copyright. All rights reserved.