SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NATURAL PRODUCT ANALOGE OF THIAZOLES

A series of 5-bromo-pyridyl containing substituted 2-amino-thiazole derivatives were synthesized by the cyclization of 2-bromo-1-(5-bromopyridin-3-yl)ethanone with different thiourea moieties and they were characterized by means of 1 H-NMR, 13 C-NMR, LCMS techniques. All the newly synthesized compounds were screened for anti-bacterial activity against Staphylococcus aureus (ATCC-9144), Staphylococcus epidermidis (ATCC-155), Bacillus cereus (ATCC-10987), Salmonella typhi (ATCC-700931), Pseudomonas aeruginosa (ATCC-2853), Escherichia coli (ATCC-25922) and antifungal activity against Aspergillus niger (ATCC-9029), Aspergillus fumigatus (ATCC46645) by paper disc diffusion technique. The test compounds showed significant level of activity against the bacterial and fungal organisms tested and vast scope is there to explore these new compounds as drugs.