IMPACT OF PROTON PUMP INHIBITOR USE ON THE COMPARATIVE SAFETY AND EFFECTIVENESS OF PRASUGREL VERSUS CLOPIDOGREL: INSIGHTS FROM TRANSLATE-ACS

Proton pump inhibitors (PPIs) reduce gastrointestinal bleeding events, but may alter clopidogrel metabolism. We examined the comparative effectiveness and safety of prasugrel vs. clopidogrel in the context of PPI use. The TRANSLATE-ACS observational study examined 11969 AMI patients treated with