A multifunctional embryos manipulative microfluidic chip with dynamic flow resistance trapping and CO-culture with stromal cells

In order to optimize the quality of embryos culture, more factors are used to improve the quality of embryos. This microfluidic device integrates the various functions, such as the trapping mechanism of dynamic flow resistance, and co-culture embryos with human stromal cells providing the growth factors. For the main function, embryos can be manipulated by fluidic field in the G-type co-culture chamber (GCC), which can make the embryos grow better by keeping them moving when co-culturing. It's expected that the successful rate of embryos development and the quality can be improved by constructing the suitable environment to provide the physical stimulus for the embryos.