[Transperitoneal transport of solute and IL-8 in dialysis-related peritonitis].

Objective To study the changes in solute transperitoneal transport and the IL 8 level at different time phases in dialysis related peritonitis so as to understand the mechanism of solute transperitoneal transport. Methods Forty two New Zealand white rabbits were randomly divided into three experimental groups (5 min, 24 h, and 48 h groups) and a control group. The rabbit model of peritoneal dialysis related peritonitis was created. The plasma and effluent concentration of creatinine, glucose, total proteins, and albumin were determined respectively; the D/P values of creatinine, total proteins, and albumin, and the Dn/D 0 values of glucose were calculated respectively. Results There was a significant difference in the D/P values of albumin at 120, 240, and 360 min between the 48 h group and the control group P0.05); the D/P values of total proteins significantly increased at different time points in the 48 h group compared with the control group (P0.05); there was a significant difference in the creatinine D/P values and glucose Dn/D 0 values between the 48 h group and the control group (P0.05). Compared with the control group, IL 8 and WBC obviously increased in the 48 h group (P0.05); the effluent IL 8 levels at different time points were positively correlated to the D/P values of the total proteins (P0.05). The effluent IL 8 levels at different time points after 60 min were positively correlated to the D/P values of albumin (P0.05). Conclusion The mechanism of transperitoneal transport of the different molecule solutes varies. Both IL 8 and WBC can influence solute transperitoneal transport in peritoneal dialysis related peritonitis.