Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M1 positive allosteric modulators

Abstract A series of methoxynaphthalene amides were prepared and evaluated as alternatives to quinolizidinone amide M 1 positive allosteric modulators. A methoxy group was optimal for M 1 activity and addressed key P-gp issues present in the aforementioned quinolizidinone amide series.