Effect of Artocarpus altilis fruit based-diet on liver and kidney function indices on alloxan-induced diabetic rats

BACKGROUND: The prevalence of diabetes mellitus continues to increase alarmingly in spite of years of intensive research. The need to explore alternative therapy such dietary and phytotherapy has been gaining attention in the management/treatment of diabetes mellitus. OBJECTIVE: The present research work was carried out to investigate the biochemical indices in the liver and kidney of alloxan-induced diabetic rats fed with Artocarpus altilis fruit based-diet. METHODS: Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg) in albino rats. A total of thirty two albino rats (Rattus norvegicus) were grouped into four; control (non-diabetic rat), diabetic untreated rats, diabetic rats administered with metformin daily and diabetic rats fed with Artocarpus altilis fruit based-diet groups. Biochemical indices in the serum, liver and kidney were determined. RESULTS: The results shows significant (P < 0.05) decrease in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, bilirubin, urea, creatinine and lipid peroxidation of diabetic fed with Artocarpus altilis fruit based-diet. Also diabetic rats fed with Artocarpus altilis fruit based-diet demonstrated significant increase (p < 0.05) in albumin and total protein concentrations as well as antioxidant enzymes activities when compared with diabetic untreated rats and diabetic rats administered with metformin daily. CONCLUSION: The results obtained in this study demonstrated that consumption of Artocarpus altilis fruit based-diet may ameliorate the liver and kidney function indices of alloxan-induced diabetic rats.