Abstract 13546: Persistent Epicardial Adipose Tissue Accumulation Contributes Coronary Plaque Vulnerability and Future Acute Coronary Syndrome in Non-obese, Coronary Artery Disease Patients

Introduction: Epicardial adipose tissue (EAT) is recognized as a novel risk factor for coronary artery disease (CAD) and its contribution is thought to be stronger in non-obese patients than in obese patients. However, the impact of changes in EAT accumulation on CAD prognosis remains unclear. This study aimed to investigate whether an increase of EAT volume predicts future acute coronary syndrome (ACS) events in non-obese CAD patients. Methods: This study consisted of 517 non-obese CAD patients who underwent serial multidetector computed tomography (MDCT) examinations to evaluate coronary atherosclerosis progression. All patients received comprehensive management to reduce CAD risk factors after the first MDCT examination. MDCT was repeated at 6-24 months and patients were followed-up for more than 1 year or until ACS events occurred. Results: Of 517 patients, EAT volume increased >10ml from first to second MDCT examination in 159 (31%) patients, decreased >10 ml in 91 (18%). In remaining 267 (51%) patie...