Pathogens Causing Ventilator-associated Pneumonia in ICU and Their Antimicrobial Resistance

Objective To explore the pathogens causing ventilator-associated pneumonia (VAP) in intensive care unit (ICU) and their drug-resistance,and to provide the reference for clinical rational use of drugs.Methods Eighty-seven cases of VAP in ICU were retrospectively analyzed.The sputa and secretions of lower respiratory tract were investigated by routine bacterial culture methods and the drug resistance was analyzed.Results Eighty-seven cases of VAP in ICU had the tracheal intubation through mouth or incision of trachea.Some of the patients with VAP had severe underlying disease.Totally 124 strains of pathogens were found,the majority of the pathogens was Gram-negative bacteria (60.5%),in which 20 strains of Klebsiella pneumoniae ranked the first (16.1%,),followed by 14 strains of Escherichia coli (11.3%) and 13 strains of Pseudomonas aeruginosa (10.5%).33 strains of the pathogens (26.6%) were the Gram-positive bacteria,including 12 strains of MRSA (9.7%) and 9 strains of MRCNS (7.3%).There were 16 strains of fungus (12.9%),and the majority was Candida albicans.The results indicated that all the bacteria showed higher drug-resistance to common antibiotics,especially Gram-negative bacteria.Conclusions All the pathogens causing VAP in ICU show higher drug-resistance to common antibiotics.We must strengthen monitoring and controlling of VAP to improve the clinical diagnosis and treatment.