The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation
2008
A cassette of cytoplasmic Drosophila tumor suppressors, including
the kinases Hippo and Warts, has recently been linked to the transmembrane
tumor suppressor Fat. These proteins act within interconnected signaling
pathways, the principal functions of which are to control the growth and
polarity of developing tissues. Recent studies have enhanced our understanding
of the basis for signal transduction by Fat and Warts pathways, including the
identification of a DNA-binding protein at the end of the pathway, have
established the conservation of Fat and Warts signaling from flies to mammals,
and have given us new insights into their regulation and biological
functions.
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