The Clinical Observation of Tamsulosin Combined with Zhi Bai Di Huang Pill for the Treatment of Benign Prostatic Heperplasia in the Eldely

Objective To study the curative effect of zhi bai di huang pill combined with α1 receptor blocker with high selectivity-tamsulosin on benign prostatic hyperplasia(BPH).Methods 118 patients with BPH were randomly divided into the treatment group and control group.The patients in treatment group were given zhi bai di huang pill combined with tamsulosin once a day before sleeping.The patients in control group were given only tamsulosin once a day before sleeping.All the patients were treated for 8 weeks.The changes of symptoms such as nocturnal frequency,urinary and urination situation,quality of life(QOL) scores and internatianal-prognosic-scoring-system(IPSS) scores and the weight of prostate and residual urine before and after treatment in the two groups were detected.Results There were no patients with abnormal liver and renal function after treatment.After 8 weeks,in the two groups the symptoms of patients' nocturnal frequency,thin urine flow,short range and weak urinary were improved.Compared to the pretherapy,QOL and IPSS scores after treatment were lower(P 0.05),residual urine significantly reduced(P 0.05).After treatment,the IPSS,residual urine in the treatment group were significantly lower than those of the control group(P 0.01).Conclusion Zhi bai di huang pill combined with tamsulosin for the treatment of BPH can effectively improve the patients' subjective symptoms and objective parameters,and there are no obvious side effects,which indicates that the combination of two drugs is more ideal for the treatment of BPH.