A Randomized Trial of Adjuvant Chemotherapy and Immunotherapy in Cutaneous Melanoma
1983
Abstract In a randomized trial of adjuvant chemotherapy, immunotherapy, or immunochemotherapy, 761 evaluable patients with pathological Stage II cutaneous melanoma anywhere on the body or with pathological Stage I melanoma of the trunk (Clark's level 3 to 5) were studied by the World Health Organization International Melanoma Group. Wide local excision and excisional regional lymphadenectomy alone were performed in 185 patients and the results were compared with those of surgery plus chemotherapy with dacarbazine (in 192 patients), surgery plus immunotherapy with bacille Calmette–Guerin vaccine (in 203), and surgery plus chemotherapy combined with immunotherapy (in 181). The rates of disease-free survival and overall survival at 36 months were 30.4±8.3 per cent (mean ±S.E.) and 41.6±10.0 per cent, respectively, after surgical treatment alone; 37.2±7.9 per cent and 46.5±8.3 per cent after surgery plus chemotherapy; 34.8±7.9 per cent and 48.7±8.7 per cent after surgery plus immunotherapy; and 33.6±7.9 per c...
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