Stability of operational taxonomic units: an important but neglected property for analyzing microbial diversity

Yan He,J. Gregory Caporaso,Xiao-Tao Jiang,Hua-Fang Sheng,Susan M. Huse,Jai Ram Rideout,Robert C. Edgar,Evguenia Kopylova,William Anton Walters,Rob Knight,Hong-Wei Zhou

Stability of operational taxonomic units: an important but neglected property for analyzing microbial diversity

2015

Yan He
J. Gregory Caporaso
Xiao-Tao Jiang
Hua-Fang Sheng
Susan M. Huse
Jai Ram Rideout
Robert C. Edgar
Evguenia Kopylova
William Anton Walters
Rob Knight
Hong-Wei Zhou

Background The operational taxonomic unit (OTU) is widely used in microbial ecology. Reproducibility in microbial ecology research depends on the reliability of OTU-based 16S ribosomal subunit RNA (rRNA) analyses.

Keywords:

Ribosomal RNA
Operational taxonomic unit
Genetics
Average Linkage
Biology
Single Linkage
Ecology
Microbiology
Microbial ecology
Rarefaction (ecology)
Reference genome
Computational biology
Cluster analysis
Ordination
microbial diversity
Multidimensional scaling

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